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Double trouble in human aneuploidy

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Crossing over, or reciprocal recombination, is essential for accurate segregation of homologous chromosomes at the first meiotic division, resulting in gametes containing the correct chromosome number. A new study in human oocytes analyzes the genome-wide recombination and segregation patterns in all the products of female meiosis, providing experimental support for existing theories about the origin of human aneuploidies and highlighting a novel reverse segregation mechanism of chromosome segregation during meiosis.

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Figure 1: Altered recombination or cohesin dynamics lead to reverse segregation in human oocytes.

References

  1. Hassold, T. & Hunt, P. Nat. Rev. Genet. 2, 280–291 (2001).

    Article  CAS  Google Scholar 

  2. Nagaoka, S.I., Hassold, T.J. & Hunt, P.A. Nat. Rev. Genet. 13, 493–504 (2012).

    Article  CAS  Google Scholar 

  3. Pratto, F. et al. Science 346, 1256442 (2014).

    Article  Google Scholar 

  4. Hou, Y. et al. Cell 155, 1492–1506 (2013).

    Article  CAS  Google Scholar 

  5. Otollini, C.S. et al. Nat. Genet. 47, 727–735 (2015).

    Article  Google Scholar 

  6. Lenzi, M.L. et al. Am. J. Hum. Genet. 76, 112–127 (2005).

    Article  CAS  Google Scholar 

  7. Suja, J.A. & Barbero, J.L. Genome Dyn. 5, 94–116 (2009).

    Article  CAS  Google Scholar 

  8. Prieto, I. et al. Chromosome Res. 12, 197–213 (2004).

    Article  CAS  Google Scholar 

  9. Garcia-Cruz, R. et al. Hum. Reprod. 25, 2316–2327 (2010).

    Article  CAS  Google Scholar 

  10. Jessberger, R. EMBO Rep. 13, 539–546 (2012).

    Article  CAS  Google Scholar 

  11. Tease, C., Hartshorne, G.M. & Hulten, M.A. Am. J. Hum. Genet. 70, 1469–1479 (2002).

    Article  CAS  Google Scholar 

  12. Cabral, G., Marques, A., Schubert, V., Pedrosa-Harand, A. & Schlogelhofer, P. Nat. Commun. 5, 5070 (2014).

    Article  CAS  Google Scholar 

  13. Heckmann, S. et al. Nat. Commun. 5, 4979 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Miguel A. Brieño-Enríquez and Paula E. Cohen are in the Department of Biomedical Sciences and the Center for Reproductive Genomics, Cornell University, Ithaca, New York, USA.,

    Miguel A Brieño-Enríquez & Paula E Cohen

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  1. Miguel A Brieño-Enríquez
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  2. Paula E Cohen
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Correspondence to Paula E Cohen.

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The authors declare no competing financial interests.

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Brieño-Enríquez, M., Cohen, P. Double trouble in human aneuploidy. Nat Genet 47, 696–698 (2015). https://doi.org/10.1038/ng.3344

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