Skip to main content
SpringerLink
Log in

Pseudomonas aeruginosa adaptation to human hosts

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Bacterial whole-genome sequencing of longitudinally collected isolates enables the investigation of evolutionary trajectories, which may inform both the prevention and treatment of human-associated pathogen infections. A new study explores the adaptation of multiple lineages of Pseudomonas aeruginosa to the lungs of young patients with cystic fibrosis and finds evidence of convergent molecular evolution and historical contingencies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Convergent evolution and historical contingency of P. aeruginosa adaptation to a human host.

Marina Corral Spence/Nature Publishing Group

References

  1. Rasko, D.A. & Sperandio, V. Nat. Rev. Drug Discov. 9, 117–128 (2010).

    Article  CAS  Google Scholar 

  2. Imamovic, L. & Sommer, M.O. Sci. Transl. Med. 5, 204ra132 (2013).

    Article  Google Scholar 

  3. Marvig, R.L., Sommer, L.M., Molin, S. & Johansen, H.K. Nat. Genet. 47, 57–64 (2015).

    Article  CAS  Google Scholar 

  4. Barrick, J.E. et al. Nature 461, 1243–1247 (2009).

    Article  CAS  Google Scholar 

  5. Folkesson, A. et al. Nat. Rev. Microbiol. 10, 841–851 (2012).

    Article  CAS  Google Scholar 

  6. Burns, J.L. et al. J. Infect. Dis. 183, 444–452 (2001).

    Article  CAS  Google Scholar 

  7. Smith, E.E. et al. Proc. Natl. Acad. Sci. USA 103, 8487–8492 (2006).

    Article  CAS  Google Scholar 

  8. Lieberman, T.D. et al. Nat. Genet. 43, 1275–1280 (2011).

    Article  CAS  Google Scholar 

  9. Lieberman, T.D. et al. Nat. Genet. 46, 82–87 (2014).

    Article  CAS  Google Scholar 

  10. Yang, L. et al. Proc. Natl. Acad. Sci. USA 108, 7481–7486 (2011).

    Article  CAS  Google Scholar 

  11. Harrison, F. Microbiology 153, 917–923 (2007).

    Article  CAS  Google Scholar 

  12. Zhang, Q. et al. Science 333, 1764–1767 (2011).

    Article  CAS  Google Scholar 

  13. Murray, J.L., Connell, J.L., Stacy, A., Turner, K.H. & Whiteley, M. J. Microbiol. 52, 188–199 (2014).

    Article  Google Scholar 

  14. Ng, K.M. et al. Nature 502, 96–99 (2013).

    Article  CAS  Google Scholar 

  15. Buffie, C.G. et al. Nature doi:10.1038/nature13828 (22 October 2014).

Download references

Author information

Authors and Affiliations

  1. Julia A. Segre is at the National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.,

    Julia A Segre

  2. Evan S. Snitkin is at the Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.,

    Evan S Snitkin

Authors
  1. Evan S Snitkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julia A Segre
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Evan S Snitkin or Julia A Segre.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Snitkin, E., Segre, J. Pseudomonas aeruginosa adaptation to human hosts. Nat Genet 47, 2–3 (2015). https://doi.org/10.1038/ng.3172

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3172

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation