Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
References
Schwartz, Y.B. & Pirrotta, V. Nat. Rev. Genet. 8, 9–22 (2007).
Di Croce, L. & Helin, K. Nat. Struct. Mol. Biol. 20, 1147–1155 (2013).
Hekimoglu, B. & Ringrose, L. RNA Biol. 6, 129–137 (2009).
Natoli, G. & Andrau, J.-C. Annu. Rev. Genet. 46, 1–19 (2012).
Herzog, V.A. et al. Nat. Genet. 46, 973–981 (2014).
Schwartz, Y.B. et al. Nat. Genet. 38, 700–705 (2006).
Davidovich, C. et al. Nat. Struct. Mol. Biol. 20, 1250–1257 (2013).
Cifuentes-Rojas, C. et al. Mol. Cell 55, 171–185 (2014).
Kim, T.K. et al. Nature 465, 182–187 (2010).
Lam, M.T. et al. Trends Biochem. Sci. 39, 170–182 (2014).
Wang, K.C. et al. Nature 472, 120–124 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Quinn, J., Chang, H. RNA switch at enhancers. Nat Genet 46, 929–931 (2014). https://doi.org/10.1038/ng.3074
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3074
- Springer Nature America, Inc.
This article is cited by
-
Biologia Futura: progress and future perspectives of long non-coding RNAs in forest trees
Biologia Futura (2022)