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Cancer gene discovery goes mobile

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A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.

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Figure 1: The cancer gene road trip.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Louise van der Weyden, Marco Ranzani and David J. Adams are at Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.,

    Louise van der Weyden, Marco Ranzani & David J Adams

Authors
  1. Louise van der Weyden
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  2. Marco Ranzani
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  3. David J Adams
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Correspondence to David J Adams.

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The authors declare no competing financial interests.

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van der Weyden, L., Ranzani, M. & Adams, D. Cancer gene discovery goes mobile. Nat Genet 46, 928–929 (2014). https://doi.org/10.1038/ng.3072

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