Two new loci for premature fusion of the cranial sutures in humans suggest a common endpoint in osteoblast regulation, linking upregulation of phosphorylated ERK1/2 and TWIST1 haploinsufficiency.
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References
Twigg, S.R.F. et al. Nat. Genet. 45, 308–313 (2013).
Sharma, V.P. et al. Nat. Genet. 45, 304–307 (2013).
Muenke, M. et al. Nat. Genet. 8, 269–274 (1994).
Reardon, W. et al. Nat. Genet. 8, 98–103 (1994).
Muenke, M. et al. Am. J. Hum. Genet. 60, 555–564 (1997).
White, K.E. et al. Am. J. Hum. Genet. 76, 361–367 (2005).
Neilson, K.M. & Friesel, R.E. J. Biol. Chem. 270, 26037–26040 (1995).
Eswarakumar, V.P., Horowitz, M.C., Locklin, R., Morriss-Kay, G.M. & Lonai, P. Proc. Natl. Acad. Sci. USA 101, 12555–12560 (2004).
Le Gallic, L., Virgilio, L., Cohen, P., Biteau, B. & Mavrothalassitis, G. Mol. Cell Biol. 24, 1206–1218 (2004).
el Ghouzzi, V. et al. Nat. Genet. 15, 42–46 (1997).
Howard, T.D. et al. Nat. Genet. 15, 36–41 (1997).
Miraoui, H., Severe, N., Vaudin, P., Pages, J.C. & Marie, P.J. J. Cell Biochem. 110, 1147–1154 (2010).
Connerney, J. et al. Dev. Dyn. 235, 1345–1357 (2006).
Wilkie, A.O. et al. Pediatrics 126, e391–e400 (2010).
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FitzPatrick, D. Filling in the gaps in cranial suture biology. Nat Genet 45, 231–232 (2013). https://doi.org/10.1038/ng.2557
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DOI: https://doi.org/10.1038/ng.2557
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