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The evolutionary biography of chronic lymphocytic leukemia

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A recent study shows that the life history of chronic lymphocytic leukemia is characterized by a complex and dynamic architecture involving the development of subclones with changing dominance over time. This innovative study provides a framework to design anticipation-based chemotherapy approaches for cancer treatment.

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Figure 1: Effect of tumor heterogeneity on CLL evolution and treatment.

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Authors and Affiliations

  1. Xose S. Puente and Carlos López-Otín are in the Departamento de Bioquímica y Biología Molecular and the Instituto Universitario de Oncología (IUOPA) at the Universidad de Oviedo, Oviedo, Spain.,

    Xose S Puente & Carlos López-Otín

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  1. Xose S Puente
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  2. Carlos López-Otín
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Correspondence to Carlos López-Otín.

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The authors declare no competing financial interests.

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Puente, X., López-Otín, C. The evolutionary biography of chronic lymphocytic leukemia. Nat Genet 45, 229–231 (2013). https://doi.org/10.1038/ng.2556

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