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A tumor-specific stem cell

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Cancer stem cells are thought to share many characteristics with their normal stem cell counterparts, raising concerns about the ability to selectively target them. A new study shows that Dclk1 marks cancer, but not normal, stem cells in the intestine and that targeting this population results in adenoma collapse without affecting normal tissue.

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Figure 1: Intestinal CSCs are distinct from NSCs.

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Authors and Affiliations

  1. Ciara Metcalfe and Frederic J. de Sauvage are in the Department of Molecular Biology at Genentech, Inc., South San Francisco, California, USA.,

    Ciara Metcalfe & Frederic J de Sauvage

Authors
  1. Ciara Metcalfe
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  2. Frederic J de Sauvage
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Corresponding author

Correspondence to Frederic J de Sauvage.

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Competing interests

The authors are employees of Genentech, Inc., and F.J.d.S. owns shares of Roche.

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Metcalfe, C., de Sauvage, F. A tumor-specific stem cell. Nat Genet 45, 7–9 (2013). https://doi.org/10.1038/ng.2502

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