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Bringing the genomic landscape of small-cell lung cancer into focus

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Genomic characterization efforts in small-cell lung cancer have been complicated by the paucity of high-quality surgical resection specimens for this aggressive lung cancer subtype that is usually diagnosed at unresectable stages in small biopsies or cytology specimens. Now, two papers report genomic analyses of small-cell lung cancer, highlighting subsets of tumors driven by amplification of FGFR1, SOX2 or MYC family members or by a MYCL1 fusion oncogene, among many other recurrent alterations.

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Figure 1: Major shared versus subtype-associated cancer-related genes in the three common subtypes of lung cancer.

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Authors and Affiliations

  1. M. Catherine Pietanza is in the Department of Medicine (Thoracic Oncology Service) Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,

    M Catherine Pietanza

  2. Marc Ladanyi is in the Department of Pathology and the Human Oncology and Pathogenesis Program at the Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,

    Marc Ladanyi

Authors
  1. M Catherine Pietanza
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  2. Marc Ladanyi
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Correspondence to Marc Ladanyi.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Past and Current Clinical trials of Targeted Agents in SCLC (PDF 29 kb)

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Pietanza, M., Ladanyi, M. Bringing the genomic landscape of small-cell lung cancer into focus. Nat Genet 44, 1074–1075 (2012). https://doi.org/10.1038/ng.2415

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