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Exploring the variation within

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We usually think of an individual's cells as sharing the same genome. Challenging this notion, two new studies show that somatic mosaicism is common and can be an early herald of cancer.

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Figure 1: Populations of cells with normal karyotypes, constitutive chromosomal abnormalities or mosaic chromosomal anomalies.

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Authors and Affiliations

  1. Evan Z. Macosko and Steven A. McCarroll are in the Department of Genetics at Harvard Medical School, Boston, Massachusetts, USA, and in the Program in Medical and Population Genetics at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.,

    Evan Z Macosko & Steven A McCarroll

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  1. Evan Z Macosko
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  2. Steven A McCarroll
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The authors declare no competing financial interests.

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Macosko, E., McCarroll, S. Exploring the variation within. Nat Genet 44, 614–616 (2012). https://doi.org/10.1038/ng.2311

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