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Fine points in mapping autoimmunity

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An efficient way to design genotyping arrays for fine mapping is to group phenotypes with common biology. The first application of the Immunochip to celiac disease provides an insightful view of what this strategy can achieve.

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Figure 1: False-discovery rate (FDR) analysis can guide selection of SNPs for follow-up replication studies.

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  1. Constantin Polychronakos is at the Endocrine Genetics Laboratory, Research Institute of the McGill University Health Centre, The Montreal Children's Hospital, Montréal, Québec, Canada.,

    Constantin Polychronakos

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  1. Constantin Polychronakos
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Correspondence to Constantin Polychronakos.

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Polychronakos, C. Fine points in mapping autoimmunity. Nat Genet 43, 1173–1174 (2011). https://doi.org/10.1038/ng.1015

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