Smoking gun found for Alzheimer's

Small clumps of misfolded protein wreak havoc.

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Walsh, D. M. et al. Naturally secreted oligomers of amyloid (protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535 - 539 (2002).
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Bucciantini, M. et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416, 507 - 511 (2002).
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Authors

John Whitfield
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University of Cambridge

Whitfield, J. Smoking gun found for Alzheimer's. Nature (2002). https://doi.org/10.1038/news020402-5