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What is the optimal treatment for patients with RA who fail to respond to monotherapy with methotrexate?

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From Nature Clinical Practice Rheumatology

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References

  1. Combe B et al. (2007) EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 66: 34–45

    Article  CAS  Google Scholar 

  2. Braun J et al. (2008) Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial. Arthritis Rheum 58: 73–81

    Article  CAS  Google Scholar 

  3. van der Heijde D et al. (2006) Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. Arthritis Rheum 54: 1063–1074

    Article  CAS  Google Scholar 

  4. Schiff M et al. (2007) Efficacy and safety of abatacept or infliximab versus placebo in ATTEST: a phase III, multicenter, randomized, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis [10.1136/ard.2007.080002]

  5. van Riel PL et al. (2006) Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE study. Ann Rheum Dis 65: 1478–1483

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Helen Jaques, Editorial Assistant, Nature Clinical Practice.

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The author has received speakers' honoraria, been a consultant for and received grant/research support from the following companies: Abbott, Amgen, Bristol–Myers Squibb, Roche, Schering and Wyeth.

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Haraoui, B. What is the optimal treatment for patients with RA who fail to respond to monotherapy with methotrexate?. Nat Rev Rheumatol 4, 346–347 (2008). https://doi.org/10.1038/ncprheum0830

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