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Why do we need noncommercial, investigator-initiated clinical trials?

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References

  1. Choy EH et al. Immunosuppressant and immunomodulatory treatment for dermatomyositis and polymyositis. Cochrane Database Of Systematic Reviews 2005, Issue 3. Art. No.: CD003643. 10.1002/14651858.CD003643.pub2

    Google Scholar 

  2. The European Parliament and the Council of the European Union (2001) Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use. Official Journal of the European Communities L121: 34–44

  3. Markman JR and Markman M (2007) Running an ethical trial 60 years after the Nuremberg Code. Lancet Oncol 8: 1139–1146

    Article  Google Scholar 

  4. Goodyear MD et al. (2007) The Declaration of Helsinki. BMJ 335: 624–625

    Article  Google Scholar 

  5. Carlson RV et al. (2004) The revision of the Declaration of Helsinki: past, present and future. Br J Clin Pharmacol 57: 695–713

    Article  Google Scholar 

  6. Kelleher F (2004) The pharmaceutical industry's responsibility for protecting human subjects of clinical trials in developing nations. Columbia J Law Soc Probl 38: 67–106

    PubMed  Google Scholar 

  7. Edwards JC and Cambridge G (2001) Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford) 40: 205–211

    Article  CAS  Google Scholar 

  8. Wagner-Bohn A et al. (2007) Implementing Good Clinical Practice in two noncommercial phase II studies in children with cancer. Onkologie 30: 21–26

    PubMed  Google Scholar 

  9. Halpern SD et al. (2002) The continuing unethical conduct of underpowered clinical trials. JAMA 288: 358–362

    Article  Google Scholar 

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Acknowledgements

The author would like to thank Zoe Doran of the European Group for Blood and Marrow Transplantation for sharing her extensive knowledge and experience in this field.

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  1. Department of Rheumatology, University Hospital, Felix Platter Spital, Burgfelderstrasse 101, 4012 Basel, Switzerland alan.tyndall@fps-basel.ch

Authors and Affiliations

  1. A Tyndall is Professor and Head of the Department of Rheumatology, University of Basel, Switzerland.,

    Alan Tyndall

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  1. Alan Tyndall
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Competing interests

A Tyndall is chairman of the European League Against Rheumatism (EULAR) Standing Committee for International Studies Including Therapeutic Trials (ESCISIT), co-chair of the EULAR and European Group for Blood and Marrow Transplantation (EBMT) hematopoietic stem cell trial in scleroderma, acting chair of three National Institute of Allergy and Infectious Disease Data and Safety Monitoring Boards for stem cell transplantation in autoimmune diseases and his department is participating in commercial studies with Novartis, Roche and Bristol–Myers Squibb.

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Tyndall, A. Why do we need noncommercial, investigator-initiated clinical trials?. Nat Rev Rheumatol 4, 354–355 (2008). https://doi.org/10.1038/ncprheum0814

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