References
O'Dell JR et al. (1996) Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. N Engl J Med 334: 1287–1291
O'Dell JR et al. (2000) Early sero-positive rheumatoid arthritis treatment: A 2-year, double-blind comparison of minocycline and hydroxychloroquine. Arthritis Rheum 43: S382
Kloppenburg M et al. (1994) Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial. Arthritis Rheum 37: 629–636
Tilley BC et al. (1995) Minocycline in rheumatoid arthritis: a 48-week, double-blind, placebo-controlled trial. Ann Intern Med 122: 81–89
Greenwald RA (1995) Tetracyclines may be therapeutically beneficial in rheumatoid arthritis, but not for the reasons that you think. J Clin Rheumatol 3: 190–193
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The synopsis was written by Jasmine Farsarakis, Associate Editor, Nature Clinical Practice.
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Alarcón, G. Early rheumatoid arthritis: combination therapy of doxycycline plus methotrexate versus methotrexate monotherapy. Nat Rev Rheumatol 2, 296–297 (2006). https://doi.org/10.1038/ncprheum0195
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DOI: https://doi.org/10.1038/ncprheum0195
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