Skip to main content
Log in

What is the standard chemotherapy for colorectal cancer patients with resectable liver metastases?

  • Viewpoint
  • Published:

From Nature Clinical Practice Oncology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Fong Y et al. (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230: 309–318

    Article  CAS  Google Scholar 

  2. Portier G et al. (2006) Multicenter randomized trial of adjuvant fluorouracil and folinic acid compared with surgery alone after resection of colorectal liver metastases: FFCD ACHBTH AURC 9002 trial. J Clin Oncol 24: 4976–4982

    Article  CAS  Google Scholar 

  3. Kemeny N et al. (1999) Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 341: 2039–2048

    Article  CAS  Google Scholar 

  4. Kemeny N et al. (2003) Phase I/II study of hepatic arterial therapy with floxuridine and dexamethasone in combination with intravenous irinotecan as adjuvant treatment after resection of hepatic metastases from colorectal cancer. J Clin Oncol 21: 3303–3309

    Article  CAS  Google Scholar 

  5. Kerr DJ et al. (2003) Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial. Lancet 361: 368–373

    Article  CAS  Google Scholar 

  6. Lorenz M et al. (1998) Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer: German Cooperative on Liver Metastases (Arbeitsgruppe Lebermetastasen). Ann Surg 228: 756–762

    Article  CAS  Google Scholar 

  7. Lorenz M and Müller HH (2000) Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colorectal carcinoma. J Clin Oncol 18: 243–254

    Article  CAS  Google Scholar 

  8. Nordlinger B et al. (2007) Final results of the EORTC Intergroup randomized phase III study 40983 [EPOC] evaluating the benefit of peri-operative FOLFOX4 chemotherapy for patients with potentially resectable colorectal cancer liver metastases. J Clin Oncol, 2007 ASCO Annual Meeting Proceedings 25: LBA5

    Google Scholar 

  9. Allen PJ et al. (2003) Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 7: 109–115

    Article  Google Scholar 

  10. Reddy SK et al. (2007) Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol 14: 3481–3491

    Article  Google Scholar 

  11. Andre T et al. (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350: 2343–2351

    Article  CAS  Google Scholar 

  12. Kuebler JP et al. (2007) Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 25: 2198–2204

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard M Goldberg.

Ethics declarations

Competing interests

BH O'Neil has received honoraria and research support from Pfizer and Sanofi-Aventis. RM Goldberg declared no competing interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

O'Neil, B., Goldberg, R. What is the standard chemotherapy for colorectal cancer patients with resectable liver metastases?. Nat Rev Clin Oncol 6, 14–16 (2009). https://doi.org/10.1038/ncponc1274

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc1274

  • Springer Nature Limited

Navigation