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Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum

  • Case Study
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From Nature Clinical Practice Oncology

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Abstract

Background A 64-year-old woman presented to the emergency room with a 3-month history of intermittent abdominal cramps, accompanied by nausea, vomiting, anorexia, and decreased bowel movements consistent with a partial intestinal obstruction. She had a 12-year history of peptic ulcers, which had been treated with histamine-2 blockers.

Investigations Physical examination, abdominal X-ray, abdominal CT scan, colonoscopy and assessment of gastrin levels.

Diagnosis Duodenal neuroendocrine neoplasm showing gastrin expression and stage III (T3N2M0), poorly differentiated adenocarcinoma of the cecum arising from hyperplastic polyposis.

Management Right-sided hemicolectomy with ileocolonic anastomosis, duodenal resection, leucovorin and 5-fluorouracil chemotherapy, annual colonoscopic surveillance, and polypectomy.

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Figure 1: Gastrin expression by a neuroendocrine tumor of the duodenum.

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Acknowledgements

We would like to acknowledge the genetic counselors L Kasprzak and L Palma for their assistance. This study was supported by the Canadian Institutes of Health Research (CIHR), grant No. MOP-67206.

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Authors and Affiliations

  1. Department of Pathology,

    Rashmi S Goswami, Parham Minoo, Kristi Baker, William D Foulkes & Jeremy R Jass

  2. Departments of Human Genetics and Oncology,

    Rashmi S Goswami, Parham Minoo, Kristi Baker, William D Foulkes & Jeremy R Jass

  3. McGill University, Montreal, QC, Canada

    Rashmi S Goswami, Parham Minoo, Kristi Baker, William D Foulkes & Jeremy R Jass

  4. Co-Director of the Molecular Diagnostic Laboratory at the Sir Mortimer B Davis–Jewish General Hospital, Montreal, QC, Canada

    George Chong

Authors
  1. Rashmi S Goswami
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  2. Parham Minoo
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  3. Kristi Baker
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  4. George Chong
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  5. William D Foulkes
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  6. Jeremy R Jass
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Corresponding author

Correspondence to Jeremy R Jass.

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The authors declare no competing financial interests.

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Goswami, R., Minoo, P., Baker, K. et al. Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. Nat Rev Clin Oncol 3, 281–284 (2006). https://doi.org/10.1038/ncponc0482

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  • DOI: https://doi.org/10.1038/ncponc0482

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