Skip to main content

Advertisement

Log in

EGFR mutations and molecularly targeted therapy: a new era in the treatment of lung cancer

  • Viewpoint
  • Published:

From Nature Clinical Practice Oncology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Fukuoka M et al. (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21: 2237–2246

    Article  CAS  Google Scholar 

  2. Kris MG et al. (2003) Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290: 2149–2158

    Article  CAS  Google Scholar 

  3. Shepherd FA et al. (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353: 123–132

    Article  CAS  Google Scholar 

  4. Thatcher N et al. (2005) Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366: 1527–1537

    Article  CAS  Google Scholar 

  5. Lynch TJ et al. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129–2139

    Article  CAS  Google Scholar 

  6. Paez JG et al. (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497–1500

    Article  CAS  Google Scholar 

  7. Dowell JE and Minna JD (2004) The impact of epidermal-growth-factor-receptor mutations in response to lung-cancer therapy. Nat Clin Pract Oncol 1: 2–3

    Article  Google Scholar 

  8. Tsao MS et al. (2005) Erlotinib in lung cancer—molecular and clinical predictors of outcome. N Engl J Med 353: 133–144

    Article  CAS  Google Scholar 

  9. Hirsch FR et al. (2005) Molecular analysis of EGFR gene copy number, EGFR expression and Akt activation status in advanced non-small-cell lung cancer treated with gefitinib or placebo (ISEL trial) [abstract #268a]. In Proceedings of the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: 2005 November 14–18; Philadelphia, 124–125

    Google Scholar 

  10. Cappuzzo F et al. (2005) Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97: 643–655

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Grant support: lung cancer SPORE P50CA70907

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John D Minna.

Ethics declarations

Competing interests

JE Dowell is on a speakers bureau for Genentech and receives research funding from Genentech. JD Minna receives research support from AstraZeneca and ImClone.

Supplementary information

Supplementary Table 1

EGFR mutation frequencies in specific clinical subsets of non-small-cell lung cancer patients based on a compilation of the published data.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dowell, J., Minna, J. EGFR mutations and molecularly targeted therapy: a new era in the treatment of lung cancer. Nat Rev Clin Oncol 3, 170–171 (2006). https://doi.org/10.1038/ncponc0476

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc0476

  • Springer Nature Limited

This article is cited by

Navigation