Skip to main content

Advertisement

Log in

A case of cocaine-induced basilar artery thrombosis

  • Case Study
  • Published:

From Nature Clinical Practice Neurology

View current issue Sign up to alerts

Abstract

Background A 40-year-old man presented to an emergency department with slurred speech, diplopia and agitation several hours after cocaine use. His level of consciousness rapidly dropped in the hours following presentation.

Investigations Physical examination, CT scan of the head, cerebral angiography.

Diagnosis Cocaine-induced basilar artery thrombosis.

Management Intra-arterial thombolysis, mechanical clot aspiration, intravenous abciximab, neurointensive care support, rehabilitation at a specialist stroke unit.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Brain CT scan in a patient with cocaine-induced basilar artery thrombosis.
Figure 2: Angiography in a patient with cocaine-induced basilar artery thrombosis.

References

  1. Nicholas S . et al (Eds; online July 2007) Home Office Statistical Bulletin: Crime in England and Wales 2006/07, edn 4 [http://www.homeoffice.gov.uk/rds/pdfs07/hosb1107.pdf] (accessed 27 June 2008)

  2. Daras M et al. (1994) Neurovascular complications of cocaine. Acta Neurol Scand 90: 124–129

    Article  CAS  Google Scholar 

  3. Levine SR et al. (1990) Cerebrovascular complications of the use of the “crack” form of alkaloidal cocaine. N Engl J Med 323: 699–704

    Article  CAS  Google Scholar 

  4. Treadwell SD et al. (2007) Cocaine use and stroke. Postgrad Med J 83: 389–393

    Article  CAS  Google Scholar 

  5. Krendel DA et al. (1990) Biopsy-proven cerebral vasculitis associated with cocaine abuse. Neurology 40: 1092–1094

    Article  CAS  Google Scholar 

  6. Fredericks RK et al. (1991) Cerebral vasculitis associated with cocaine use. Stroke 22: 1437–1439

    Article  CAS  Google Scholar 

  7. Sauer CM (1991) Recurrent embolic stroke and cocaine-related cardiomyopathy. Stroke 22: 1203–1205

    Article  CAS  Google Scholar 

  8. Vallee JN et al. (2003) Basilar artery occlusion treated by thromboaspiration in a cocaine and ecstasy abuser. Neurology 61: 839–841

    Article  Google Scholar 

  9. Konzen P et al. (1995) Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine. Stroke 26: 1114–1118

    Article  CAS  Google Scholar 

  10. Brandt T (2002) Diagnosis and thrombolytic therapy of acute basilar artery occlusion: a review. Clin Exp Hypertens 24: 611–622

    Article  Google Scholar 

  11. Gregory WA (1999) Expanding the window for thrombolytic therapy in acute stroke. Stroke 30: 2230–2237

    Article  Google Scholar 

  12. Voetsch B et al. (2004) Basilar artery occlusive disease in the New England Medical Center Posterior Circulation Registry. Arch Neurol 61: 496–504

    Article  Google Scholar 

  13. Eckert B et al. (2003) Acute basilar artery occlusion treated with combined intravenous abciximab and intra-arterial tissue plasminogen activator. Stroke 33: 1424–1427

    Article  Google Scholar 

  14. Bush SH (1998) Cocaine-associated myocardial infarction—a word of caution about thrombolytic therapy. Chest 94: 878

    Article  Google Scholar 

  15. Hollander J et al. (1995) Cocaine-associated myocardial infarction: clinical safety of thrombolytic therapy: Cocaine Associated Myocardial Infarction (CAMI) Study Group. Chest 107: 1237–1241

    Article  CAS  Google Scholar 

  16. Green RM et al. (1990) Multiple intracerebral haemorrhages after smoking crack cocaine. Stroke 21: 657–672

    Article  Google Scholar 

  17. Kibayashi K et al. (1995) Cocaine-induced intracerebral haemorrhage: analysis of predisposing factors and mechanisms causing haemorrhagic strokes. Hum Pathol 26: 659–663

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Désirée Lie, University of California, Irvine, CA, is the author of and is solely responsible for the content of the learning objectives, questions and answers of the Medscape-accredited continuing medical education activity associated with this article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Clare MacEwen.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

MacEwen, C., Ward, M. & Buchan, A. A case of cocaine-induced basilar artery thrombosis. Nat Rev Neurol 4, 622–626 (2008). https://doi.org/10.1038/ncpneuro0879

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpneuro0879

  • Springer Nature Limited

This article is cited by

Navigation