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The effects of hormone replacement therapy on renal function

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From Nature Clinical Practice Nephrology

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Abstract

This Practice Point commentary discusses a study by Ahmed et al. that evaluated the effects of hormone replacement therapy (conjugated estrogen alone, progestin alone or a combination of progestin and conjugated estrogen) on renal function in elderly community-dwelling postmenopausal women. The authors found that oral estrogen therapy in this population was associated with accelerated decline in kidney function over a 2-year period. In addition, the cumulative amount of estrogen intake was dose-dependently associated with the rate of renal functional decline. This commentary highlights the human and experimental evidence suggesting that endogenous and exogenous estrogen affect renal function, and discusses the possible beneficial or detrimental effects of hormone supplementation on kidney function.

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References

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Author notes

  1. Montefiore Medical Center, Department of Medicine, 111 East 210th Street, NW 6, Bronx, NY 10467, USA ssilbige@montefiore.org

Authors and Affiliations

  1. Member of the Division of Nephrology and the Director of the Internal Medicine Residency Program in the Department of Medicine at the Albert Einstein College of Medicine and Montefiore Medical Center, S Silbiger is a Professor of Clinical Medicine, Bronx, NY, USA.,

    Sharon Silbiger

Authors
  1. Sharon Silbiger
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The author declares no competing financial interests.

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Silbiger, S. The effects of hormone replacement therapy on renal function. Nat Rev Nephrol 5, 6–7 (2009). https://doi.org/10.1038/ncpneph0993

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  • DOI: https://doi.org/10.1038/ncpneph0993

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