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Nitric oxide depletion is responsible for the adverse effects of vascular endothelial growth factor inhibitors

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References

  1. Eremina V et al. (2008) VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358: 1129–1136

    Article  CAS  Google Scholar 

  2. Papapetropoulos A et al. (1997) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 100: 3131–3139

    Article  CAS  Google Scholar 

  3. Yang HT et al. (2001) VEGF121- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production. Am J Physiol Heart Circ Physiol 280: H1097–H1104

    Article  CAS  Google Scholar 

  4. Ziche M et al. (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99: 2625–2634

    Article  CAS  Google Scholar 

  5. Feliers D et al. (2005) VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells. Kidney Int 68: 1648–1659

    Article  CAS  Google Scholar 

  6. Bussolati B et al. (2001) Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. Am J Pathol 159: 993–1008

    Article  CAS  Google Scholar 

  7. Sugimoto H et al. (2003) Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 278: 12605–12608

    Article  CAS  Google Scholar 

  8. Zhu X et al. (2007) Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 49: 186–193

    Article  CAS  Google Scholar 

  9. Datta PK et al. (2006) Effect of nitric oxide synthase inhibition on proteinuria in glomerular immune injury. Exp Biol Med (Maywood) 231: 576–584

    Article  CAS  Google Scholar 

  10. Waddington S et al. (1996) L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis. Kidney Int 49: 1090–1096

    Article  CAS  Google Scholar 

  11. Miller KD et al. (2005) Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23: 792–799

    Article  CAS  Google Scholar 

  12. Cappellini MD (2007) Coagulation in the pathophysiology of hemolytic anemias. Hematology Am Soc Hematol Educ Program 2007: 74–78

    Article  Google Scholar 

  13. Dran GI et al. (2002) Protective role of nitric oxide in mice with Shiga toxin-induced hemolytic uremic syndrome. Kidney Int 62: 1338–1348

    Article  CAS  Google Scholar 

  14. Rother RP et al. (2005). The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 293: 1653–1662

    Article  CAS  Google Scholar 

  15. Thachil J (2007) Thrombotic thrombocytopenic purpura: is there more than ADAMTS-13? J Thromb Haemost 5: 634–635

    Article  CAS  Google Scholar 

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Thachil, J. Nitric oxide depletion is responsible for the adverse effects of vascular endothelial growth factor inhibitors. Nat Rev Nephrol 4, 536–537 (2008). https://doi.org/10.1038/ncpneph0907

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