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Cortistatin: not just another somatostatin analog

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From Nature Clinical Practice Endocrinology & Metabolism

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References

  1. de Lecea L et al. (1996) A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381: 242–245

    Article  CAS  Google Scholar 

  2. Spier AD and de Lecea L (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev 33: 228–241

    Article  CAS  Google Scholar 

  3. Weckbecker G et al. (2003) Opportunities in somatostatin research: biological, chemical and therapeutic aspects. Nat Rev Drug Discov 2: 999–1017

    Article  CAS  Google Scholar 

  4. Gottero C et al. (2004) Cortistatin-17 and -14 exert the same endocrine activities as somatostatin in humans. Growth Horm IGF Res 14: 382–387

    Article  CAS  Google Scholar 

  5. Schweitzer P et al. (2003) The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons. J Neurosci 23: 10884–10891

    Article  CAS  Google Scholar 

  6. Robas N et al. (2003) MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J Biol Chem 278: 44400–44404

    Article  CAS  Google Scholar 

  7. Yan S et al. (2005) TNF-α decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells. J Surg Res 123: 294–301

    Article  CAS  Google Scholar 

  8. Gonzalez-Rey E et al. (2006) Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia. J Exp Med 203: 563–571

    Article  CAS  Google Scholar 

  9. Dalm VA et al. (2003) Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system. J Clin Endocrinol Metab 88: 270–276

    Article  CAS  Google Scholar 

  10. Allia E et al. (2005) Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours. J Pathol 207: 336–345

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Associate Professor in the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA

    Luis de Lecea

  2. Associate Professor in the Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

    Justo P Castaño

Authors
  1. Luis de Lecea
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  2. Justo P Castaño
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Correspondence to Luis de Lecea.

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The authors declare no competing financial interests.

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de Lecea, L., Castaño, J. Cortistatin: not just another somatostatin analog. Nat Rev Endocrinol 2, 356–357 (2006). https://doi.org/10.1038/ncpendmet0219

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  • DOI: https://doi.org/10.1038/ncpendmet0219

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