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Mineralocorticoid-receptor blockade, hypertension and heart failure

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From Nature Clinical Practice Endocrinology & Metabolism

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References

  1. Pitt B et al. (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341: 709–717

    Article  CAS  Google Scholar 

  2. Pitt B et al. (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348: 1309–1321

    Article  CAS  Google Scholar 

  3. Pitt B et al. (2003) Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 108: 1831–1838

    Article  CAS  Google Scholar 

  4. Rocha R et al. (2002) Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 143: 4828–4836

    Article  CAS  Google Scholar 

  5. Juurlink D et al. (2004) Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 351: 543–551

    Article  CAS  Google Scholar 

  6. Bozkurt B et al. (2003) Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. J Am Coll Cardiol 41: 211–214

    Article  CAS  Google Scholar 

  7. Levy D et al. (2004) Distinguishing the antihypertensive and electrolyte effects of eplerenone. J Clin Endocrinol Metab 89: 2736–2740

    Article  CAS  Google Scholar 

  8. Funder JW et al. (1988) Mineralocorticoid action: target-tissue specificity is enzyme, not receptor, mediated. Science 242: 583–585

    Article  CAS  Google Scholar 

  9. Funder JW and Myles K (1996) Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies. Endocrinology 137: 5264–5268

    Article  CAS  Google Scholar 

  10. Funder JW (2004) Is aldosterone bad for the heart? Trends Endocrinol Metab 15: 139–142

    Article  CAS  Google Scholar 

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Correspondence to John W Funder.

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Competing interests

Dr Funder is a consultant for Eli Lilly, Merck, Pfizer, cBio, Exelisis, GNF and Kalypsis, and holds research grants from Merck and Pfizer.

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Funder, J. Mineralocorticoid-receptor blockade, hypertension and heart failure. Nat Rev Endocrinol 1, 4–5 (2005). https://doi.org/10.1038/ncpendmet0016

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