Skip to main content
SpringerLink
Log in

Bioabsorbable drug-eluting stents: the future of coronary angioplasty?

  • Clinical Advance
  • Published:

From Nature Clinical Practice Cardiovascular Medicine

View current issue Sign up to alerts

Abstract

In the ABSORB trial, the feasibility of using a fully bioabsorbable everolimus-eluting stent (BVS; Abbott Vascular, Santa Clara, CA) in patients with ischemia and a single de novo coronary lesion was investigated. Some important concerns about the efficacy of this device were raised by this study. The in-stent late loss with the BVS (0.44 mm) was comparable to that seen with some drug-eluting stents currently on the market, and the late lumen loss was primarily due to reduction in stent area. Technical improvements aimed at definitively preventing late vessel recoil and negative remodeling, as well as clarification of the behavior of these devices with longer follow-up, are needed before fully bioabsorbable drug-eluting stents can be considered a therapeutic option for patients with coronary artery disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Stettler C et al. (2007) Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 370: 937–948

    Article  CAS  Google Scholar 

  2. Jensen LO et al. (2007) Stent thrombosis, myocardial infarction, and death after drug-eluting and bare-metal stent coronary interventions. J Am Coll Cardiol 50: 463–470

    Article  CAS  Google Scholar 

  3. Erbel R et al. for the PROGRESS-AMS investigators (2007) Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial. Lancet 369: 1869–1875

    Article  CAS  Google Scholar 

  4. Ormiston JA et al. (2008) A bioabsorbable everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB): a prospective open-label trial. Lancet 371: 899–907

    Article  CAS  Google Scholar 

  5. Di Mario C and Ferrante G (2008) Biodegradable drug-eluting stents: promises and pitfalls. Lancet 371: 873–874

    Article  Google Scholar 

  6. Moreno R et al. (2007) Clinical impact of in-stent late loss after drug-eluting coronary stent implantation. Eur Heart J 28: 1583–1591

    Article  Google Scholar 

  7. Grube E et al. (2004) Six- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. Circulation 109: 2168–2171

    Article  CAS  Google Scholar 

  8. Kiemeneij F et al. (2001) Continued benefit of coronary stenting versus balloon angioplasty: five-year clinical follow-up of Benestent-I trial. J Am Coll Cardiol 37: 1598–1603

    Article  CAS  Google Scholar 

  9. Serruys PW on behalf of the SPIRIT II Investigators (2008) SPIRIT II study: a clinical evaluation of the XIENCE V everolimus-eluting coronary stent system in the treatment of patients with de novo native coronary artery lesions. Presented at the Society for Cardiovascular Angiography and Interventions and the American College of Cardiology i2 Summit (SCAI-ACCi2): 2008 March 29 to April 1, Chicago, IL

Download references

Author information

Authors and Affiliations

  1. C Macaya is the Head of the Cardiology Department in the University Hospital Clinico San Carlos and R Moreno is the Director of the Interventional Cardiology Unit at the University Hospital La Paz, both in Madrid, Spain.,

    Carlos Macaya & Raul Moreno

Authors
  1. Carlos Macaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Raul Moreno
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carlos Macaya.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Macaya, C., Moreno, R. Bioabsorbable drug-eluting stents: the future of coronary angioplasty?. Nat Rev Cardiol 5, 598–599 (2008). https://doi.org/10.1038/ncpcardio1306

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpcardio1306

  • Springer Nature Limited

Search

Navigation