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Does aprotinin increase the long-term risk of mortality in patients undergoing CABG surgery?

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From Nature Clinical Practice Cardiovascular Medicine

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References

  1. Royston D et al. (1987) Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 2: 1289–1291

    Article  CAS  Google Scholar 

  2. Sedrakyan A et al. (2004) Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg 128: 442–448

    Article  CAS  Google Scholar 

  3. Mangano DT et al. for the Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation (2006) The risk associated with aprotinin in cardiac surgery. N Engl J Med 354: 353–365

    Article  CAS  Google Scholar 

  4. Ferguson TB Jr (2007) Aprotinin—are there lessons learned? JAMA 297: 527–529

    Article  CAS  Google Scholar 

  5. Engoren MC et al. (2002) Effect of blood transfusion on long-term survival after cardiac operation. Ann Thorac Surg 74: 1180–1186

    Article  Google Scholar 

  6. Landis RC et al. (2001) The antithrombotic and anti-inflammatory mechanisms of action of aprotinin. Ann Thorac Surg 72: 2169–2175

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Alexandra King, Associate Editor, Nature Clinical Practice.

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The author has received honoraria for lectures from Bayer AG.

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Taylor, K. Does aprotinin increase the long-term risk of mortality in patients undergoing CABG surgery?. Nat Rev Cardiol 4, 416–417 (2007). https://doi.org/10.1038/ncpcardio0934

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  • DOI: https://doi.org/10.1038/ncpcardio0934

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