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Short-circuiting RNA splicing

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Isoginkgetin has been identified as a general inhibitor of pre-mRNA splicing using an in vivo screening assay. This and related inhibitors will not only be useful as tools to decipher the roles of the individual components of the spliceosome but may also serve as therapeutics.

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Figure 1: The cell-based screen to identify small molecules that inhibit pre-mRNA splicing.

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Authors and Affiliations

  1. Matthew D. Disney is in the Department of Chemistry and the New York State Center of Excellence in Bioinformatics and Life Sciences, 657 Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA. mddisney@buffalo.edu,

    Matthew D Disney

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  1. Matthew D Disney
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Disney, M. Short-circuiting RNA splicing. Nat Chem Biol 4, 723–724 (2008). https://doi.org/10.1038/nchembio1208-723

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