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Bcl-2 turns deadly

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Small-molecule inhibitors of anti-apoptotic Bcl-2 proteins and BH3 mimetic peptides are promising anticancer agents. A recent study identifies a Nur77-based peptide that converts anti-apoptotic Bcl-2 proteins into pro-apoptotic molecules, providing another potential cancer therapeutic strategy.

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Figure 1: Small molecules convert anti-death factors into pro-death factors.

Katie Ris-Vicari

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Authors and Affiliations

  1. Bing Qi and J. Marie Hardwick are in the W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205, USA. mhardwic@jhsph.edu,

    Bing Qi & J Marie Hardwick

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  1. Bing Qi
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  2. J Marie Hardwick
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Qi, B., Hardwick, J. Bcl-2 turns deadly. Nat Chem Biol 4, 722–723 (2008). https://doi.org/10.1038/nchembio1208-722

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