Multimodular scaffold proteins are ideally suited for assembling the various proteins in signaling pathways into supramolecular complexes. A recent study demonstrates that, in addition to a passive scaffolding role, a PDZ domain in a photoreceptor scaffold protein actively regulates fruit fly visual signaling via light-dependent conformational cycling.
References
Mishra, P. et al. Cell 131, 80–92 (2007).
Tsunoda, S. et al. Nature 388, 243–249 (1997).
Montell, C. Annu. Rev. Cell Dev. Biol. 15, 231–268 (1999).
Pawson, T. & Nash, P. Science 300, 445–452 (2003).
Feng, W., Shi, Y., Li, M. & Zhang, M. Nat. Struct. Biol. 10, 972–978 (2003).
Long, J.F. et al. Nat. Struct. Mol. Biol. 12, 722–728 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zhang, M. Scaffold proteins as dynamic switches. Nat Chem Biol 3, 756–757 (2007). https://doi.org/10.1038/nchembio1207-756
Issue Date:
DOI: https://doi.org/10.1038/nchembio1207-756
- Springer Nature America, Inc.
This article is cited by
-
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Nature Reviews Neuroscience (2009)