Ascidians obtain diverse libraries of cytotoxic compounds by maintaining cyanobacterial symbionts that have combinatorial variants of a natural-product pathway. The biosynthetic flexibility of this route can be used to genetically engineer new substances.
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Piel, J. Combinatorial biosynthesis in symbiotic bacteria. Nat Chem Biol 2, 661–662 (2006). https://doi.org/10.1038/nchembio1206-661
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DOI: https://doi.org/10.1038/nchembio1206-661
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