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Proteolytic needles in the cellular haystack

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The execution phase of cell death is driven by specific proteolytic signaling through cleavage of proteins by caspases. Within the mix of hundreds of newly identified caspase substrates lie the crucial proteolytic events whose sum defines the unique morphology known as apoptosis.

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Figure 1: Detection of protease substrates by proteomics.

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Authors and Affiliations

  1. Mari Enoksson and Guy S. Salvesen are in the Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA. gsalvesen@burnham.org,

    Mari Enoksson & Guy S Salvesen

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  1. Mari Enoksson
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  2. Guy S Salvesen
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Enoksson, M., Salvesen, G. Proteolytic needles in the cellular haystack. Nat Chem Biol 4, 651–652 (2008). https://doi.org/10.1038/nchembio1108-651

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