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The emerging biology of the nitrite anion

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A Corrigendum to this article was published on 01 February 2006

Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics.

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Figure 1: Nitrite chemistry, physiology and therapeutics.
Figure 2: Origin and interconversion of nitric oxide (NO) and nitrite (NO2−) and their role in cell signaling and gene expression.
Figure 3: Nitrite reductase activity of hemoglobin.
Figure 4: The human nitrogen cycle.

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Acknowledgements

We would like to thank other session chairs, including H. Franklin Bunn, A. Butler, M. Doyle, D. Lefer, G. Mauk, C.S. Raman and J.L. Zweier, for their valuable scientific and organizational contributions to this meeting. This meeting was generously funded by the Office of Rare Diseases, the National Heart, Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Neurological Disorders and Stroke and the Clinical Center of the National Institutes of Health. The meeting was also sponsored by the University of Pittsburgh School of Medicine, Wake Forest University, and the Medical College of Wisconsin. Additional information on speakers and presentations can be found at http://www.strategicresults.com/nitrite.

Author information

Authors and Affiliations

  1. Vascular Medicine Branch, National Heart, Lung, and Blood Institute,

    Mark T Gladwin

  2. the Critical Care Medicine Department, Clinical Center, US National Institutes of Health, Bethesda, Maryland, USA

    Mark T Gladwin

  3. National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA

    Alan N Schechter

  4. Department of Physics, Wake Forest University, North Carolina, USA

    Daniel B Kim-Shapiro

  5. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Rakesh P Patel & Jack R Lancaster Jr

  6. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Neil Hogg

  7. Vascular Medicine Branch,

    Sruti Shiva & Richard O Cannon III

  8. Cardiovascular Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA

    Sruti Shiva & Richard O Cannon III

  9. Heinrich-Heine-Universität, Düsseldorf, Germany

    Malte Kelm

  10. National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA

    David A Wink & Michael Graham Espey

  11. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA

    Edward H Oldfield & Ryszard M Pluta

  12. Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Bruce A Freeman

  13. Boston University School of Medicine, Boston, Massachusetts, USA

    Martin Feelisch

  14. Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden

    Jon O Lundberg

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  1. Mark T Gladwin
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  2. Alan N Schechter
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  14. Jack R Lancaster Jr
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  15. Martin Feelisch
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  16. Jon O Lundberg
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Correspondence to Mark T Gladwin.

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Gladwin, M., Schechter, A., Kim-Shapiro, D. et al. The emerging biology of the nitrite anion. Nat Chem Biol 1, 308–314 (2005). https://doi.org/10.1038/nchembio1105-308

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