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A proton-controlled check valve for sodium ion transport

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Transmembrane electrochemical ion gradients are the thermodynamic forces exploited by living cells to drive specific substances across the membrane. A new study begins to reveal the molecular mechanisms by which a transporter protein harnesses these driving forces.

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Figure 1: Representation of the alternating accessibility mechanism in the Na+/H+ antiporter NhaA.

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Authors and Affiliations

  1. Benoît Roux is in the Gordon Center for Integrative Sciences, University of Chicago, 929 East 57th Street, Chicago, Illinois 60627, USA. roux@uchicago.edu,

    Benoît Roux

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  1. Benoît Roux
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The author declares no competing financial interests.

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Roux, B. A proton-controlled check valve for sodium ion transport. Nat Chem Biol 3, 609–610 (2007). https://doi.org/10.1038/nchembio1007-609

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  • DOI: https://doi.org/10.1038/nchembio1007-609

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