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A carbohydrate vaccine exceeds the sum of its parts

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A fully synthetic three-component vaccine has been shown to induce high titers of antibodies against the mucin Tn antigen of human cancer cells. The vaccine's superior properties are a result of the covalent incorporation of a ligand for Toll-like receptors and the presentation of the vaccine in a liposome format.

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Figure 1: The lipophilic Toll-like receptor (TLR) ligand locates the synthetic vaccine in the membrane of the liposome with the B epitope exposed to bind to the immunoglobulin receptor of a B cell.

Katie Ris-Vicari

References

  1. Ingale, S. et al. Nat. Chem. Biol. 3, 663–667 (2007).

    Article  CAS  Google Scholar 

  2. Lucas, A.H. Clin. Infect. Dis. 41, 705–712 (2005).

    Article  CAS  Google Scholar 

  3. Livingston, P.O. Immunol. Rev. 145, 147–166 (1995).

    Article  CAS  Google Scholar 

  4. Livingston, P.O. & Ragupathi, G. Hum. Vaccin. 2, 137–143 (2006).

    Article  CAS  Google Scholar 

  5. Danishefsky, S.J. & Allen, J.R. Angew. Chem. Int. Ed. 39, 836–863 (2000).

    Article  CAS  Google Scholar 

  6. Wille-Reece, U. et al. Proc. Natl. Acad. Sci. USA 102, 15190–15194 (2005).

    Article  CAS  Google Scholar 

  7. Plante, O.J. Science 291, 1523–1527 (2001).

    Article  CAS  Google Scholar 

  8. Carrel, F.R. et al. Org. Lett. 9, 2285–2288 (2007).

    Article  CAS  Google Scholar 

  9. Wong, C.-H. et al. Angew. Chem. Int. Ed. 34, 412–432 (2003).

    Article  Google Scholar 

  10. Hancock, S.M. et al. Curr. Opin. Chem. Biol. 10, 509–519 (2006).

    Article  CAS  Google Scholar 

  11. Antoine, T. et al. Chembiochem 4, 406–412 (2003).

    Article  CAS  Google Scholar 

  12. Kowarik, M. et al. Science 314, 1148–1150 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. David R. Bundle is in the Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada. dave.bundle@ualberta.ca,

    David R Bundle

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  1. David R Bundle
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Competing interests

D.R.B. receives funding to pursue research on topics related to the research described, and may act as a consultant to companies active in vaccine research and development.

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Bundle, D. A carbohydrate vaccine exceeds the sum of its parts. Nat Chem Biol 3, 605–606 (2007). https://doi.org/10.1038/nchembio1007-605

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  • DOI: https://doi.org/10.1038/nchembio1007-605

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