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Engineering a multipurpose catalyst

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D-Amino acids can be useful building blocks for pharmaceuticals, but synthesizing them at a low cost remains challenging. A good catalyst for generating unnatural D-amino acids has been created by expanding the substrate range of a highly specific dehydrogenase.

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Figure 1: Converting a single-purpose enzyme to a multipurpose enzyme for synthesis.

Katie Ris

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Kazlauskas, R. Engineering a multipurpose catalyst. Nat Chem Biol 2, 514–515 (2006). https://doi.org/10.1038/nchembio1006-514

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  • DOI: https://doi.org/10.1038/nchembio1006-514

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