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Nitrite as an intrinsic signaling molecule

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Nitrite, a ubiquitous stable oxidation byproduct of nitric oxide (NO) metabolism, is now entering the pantheon of signaling biochemical molecules. Nitrite may have the unique properties of a blood and tissue NO reservoir activated by physiological and pathological hypoxia.

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Figure 1: Nitrite is reduced to NO along the physiological oxygen and pH gradient to form NO, S-nitrosothiols, N-nitrosamines, iron-nitrosyl complexes and possibly nitrated lipids.

References

  1. Cosby, K. et al. Nat. Med. 9, 1498–1505 (2003).

    Article  CAS  Google Scholar 

  2. Duranski, M.R. et al. J. Clin. Invest. 115, 1232–1240 (2005).

    Article  CAS  Google Scholar 

  3. Bryan, N.S. et al. Nat. Chem. Biol. 1, 290–297 (2005).

    Article  CAS  Google Scholar 

  4. Furchgott, R.F. & Bhadrakom, S. J. Pharmacol. Exp. Ther. 108, 129–143 (1953).

    CAS  Google Scholar 

  5. Zweier, J.L., Wang, P. Samouilov, A. & Kuppusamy, P. Nat. Med. 1, 804–809 (1995).

    Article  CAS  Google Scholar 

  6. Bjorne, H.H. et al. J. Clin. Invest. 113, 106–114 (2004).

    Article  Google Scholar 

  7. Huang, Z. et al. J. Clin. Invest. 115, 2099–2107 (2005).

    Article  CAS  Google Scholar 

  8. Doyle, M.P., Pickering, R.A., DeWeert, T.M., Hoekstra, J.W. & Pater, D. J. Biol. Chem. 256, 12393–12398 (1981).

    CAS  Google Scholar 

  9. Fernandez, B.O., Lorkovic, I.M. & Ford, P.C. Inorg. Chem. 42, 2–4 (2003).

    Article  CAS  Google Scholar 

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  1. Vascular Medicine Branch of the National Heart, Lung, and Blood Institute at the US National Institutes of Health, Bethesda, 20892, Maryland, USA

    Mark T Gladwin

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  1. Mark T Gladwin
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Gladwin, M. Nitrite as an intrinsic signaling molecule. Nat Chem Biol 1, 245–246 (2005). https://doi.org/10.1038/nchembio1005-245

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