A small-molecule inhibitor of the obligate dimeric protease of human Kaposi's sarcoma–associated herpesvirus was identified. The agent functions by a 'monomer trap' mechanism in which the compound binds to a partially unfolded monomer and disrupts the formation of the enzymatically active protease dimer.
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Chmielewski, J. Protease dimer formation disrupted. Nat Chem Biol 5, 607–608 (2009). https://doi.org/10.1038/nchembio0909-607
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DOI: https://doi.org/10.1038/nchembio0909-607
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