Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.
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Kirshenbaum, K., Arora, P. Cross-dressing proteins by olefin metathesis. Nat Chem Biol 4, 527–528 (2008). https://doi.org/10.1038/nchembio0908-527
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DOI: https://doi.org/10.1038/nchembio0908-527
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