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Unexpected N-terminal editing: a cysteine protease that cuts and pastes

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N-terminal modification is a mechanism for regulation of protein activity, localization and degradation. A proteomic approach using β-lactone activity-based probes has identified a cysteine protease with N-terminal transpeptidase activity.

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Figure 1: β-Lactone and peptide labeling of RD21 substrates.

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Authors and Affiliations

  1. Department of Chemistry, Isaac Carrico is in the Institute of Chemical Biology and Drug Discovery, Stony Brook University, 1 John S. Toll Road, Stony Brook, New York 11794-3400, USA. isaac.carrico@sunysb.edu,

    Isaac Carrico

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  1. Isaac Carrico
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Carrico, I. Unexpected N-terminal editing: a cysteine protease that cuts and pastes. Nat Chem Biol 4, 525–526 (2008). https://doi.org/10.1038/nchembio0908-525

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  • DOI: https://doi.org/10.1038/nchembio0908-525

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