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One-way traffic control in replication termination

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Tus proteins bound to multiple ter sequences on DNA determine the site of DNA replication termination in Escherichia coli. Biochemical and structural studies reveal how the Tus–ter complex arrests replication forks in a direction-sensitive manner.

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Figure 1: Traffic control for replisomes: two replisomes work in opposite directions to replicate circular genomic DNA (red lines) of E. coli.

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  1. the Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, 01002, Massachusetts, USA

    Karsten Theis

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  1. Karsten Theis
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Theis, K. One-way traffic control in replication termination. Nat Chem Biol 2, 455–456 (2006). https://doi.org/10.1038/nchembio0906-455

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