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Linking physiological functions of iron

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Iron-sulfur clusters and hemes are two iron-containing prosthetic groups involved in important physiological functions. Identification of the gene responsible for anemia in a mutant zebrafish has revealed an unexpected link between iron-sulfur cluster assembly and heme synthesis in red blood cells.

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Figure 1: IRP1 that lacks an iron-sulfur cluster because of glutaredoxin 5 deficiency represses heme synthesis by repressing translation of the first enzyme of the heme biosynthetic pathway.

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Authors and Affiliations

  1. Section on Human Iron Metabolism at the US National Institutes of Health, Bethesda, 20892, Maryland, USA

    Tracey A Rouault

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  1. Tracey A Rouault
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Rouault, T. Linking physiological functions of iron. Nat Chem Biol 1, 193–194 (2005). https://doi.org/10.1038/nchembio0905-193

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