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A glimpse at the grail

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Voltage-gated ion channels respond to alterations in membrane potential and mediate action potential in neurons. A recent study provides new insights into the structure and gating of the Shaker potassium channel.

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Figure 1: X-ray structure of an open Kv1.2 channel in complex with a β2 subunit (PDB 2A79).

References

  1. Long, S.B., Campbell, E.B. & MacKinnon, R. Science, published online 7 July 2005 (10.1126/science.1116269).

  2. Long, S.B., Campbell, E.B. & MacKinnon, R. Science, published online 7 July 2005 (10.1126/science.1116270).

  3. Kuo, A. et al. Science 300, 1922–1926 (2003).

    Article  CAS  Google Scholar 

  4. MacKinnon, R. Angew. Chem. Int. Edn. Engl. 43, 4265–4277 (2004).

    Article  CAS  Google Scholar 

  5. Jiang, Y.X., Ruta, V., Chen, J.Y., Lee, A. & MacKinnon, R. Nature 423, 42–48 (2003).

    Article  CAS  Google Scholar 

  6. Zagotta, W.N., Hoshi, T. & Aldrich, R.W. Science 250, 568–571 (1990).

    Article  CAS  Google Scholar 

  7. Gradl, S.N., Felix, J.P., Isacoff, E.Y., Garcia, M.L. & Trauner, D. J. Am. Chem. Soc. 125, 12668–12669 (2003).

    Article  CAS  Google Scholar 

  8. Banghart, M., Borges, K., Isacoff, E., Trauner, D. & Kramer, R.H. Nat. Neurosci. 7, 1381–1386 (2004).

    Article  CAS  Google Scholar 

  9. Murata, Y., Iwasaki, H., Sasaki, M., Inaba, K. & Okamura, Y. Nature 435, 1239–1243 (2005).

    Article  CAS  Google Scholar 

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  1. Department of Chemistry at the University of California, Berkeley, 602 Latimer Hall, Berkeley, 94720-1460, California, USA

    Dirk Trauner

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  1. Dirk Trauner
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Trauner, D. A glimpse at the grail. Nat Chem Biol 1, 189–191 (2005). https://doi.org/10.1038/nchembio0905-189

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  • DOI: https://doi.org/10.1038/nchembio0905-189

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