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How evolving enzymes can beat the heat and avoid defeat

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Random mutations usually destabilize protein tertiary structure. Overexpression of the chaperonin GroEL/GroES protects evolving proteins from the destabilizing effects of adaptive mutations and improves the quantity and quality of enzyme variants with modified function.

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Figure 1: Chaperonin overexpression accelerates adaptive protein evolution.

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Authors and Affiliations

  1. Ichiro Matsumura and Andrei A. Ivanov are in the Department of Biochemistry, Center for Fundamental and Applied Molecular Evolution, Emory University School of Medicine, Atlanta, Georgia, USA.,

    Ichiro Matsumura & Andrei A Ivanov

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  1. Ichiro Matsumura
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  2. Andrei A Ivanov
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Correspondence to Ichiro Matsumura.

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Matsumura, I., Ivanov, A. How evolving enzymes can beat the heat and avoid defeat. Nat Chem Biol 5, 538–539 (2009). https://doi.org/10.1038/nchembio0809-538

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  • DOI: https://doi.org/10.1038/nchembio0809-538

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