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Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer

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Chemical probes reveal Hsp90 to be a key molecule for the control of apoptosis in small-cell lung cancer—with important implications for Hsp90 biology and cancer treatment.

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Figure 1: Inhibition of Hsp90 leads to apoptosis in small-cell lung cancer (SCLC).

Kim Caesar

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Authors and Affiliations

  1. Paul Workman and Marissa V. Powers are in the Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. paul.workman@icr.ac.uk,

    Paul Workman & Marissa V Powers

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  1. Paul Workman
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  2. Marissa V Powers
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Competing interests

P.W. has been involved in a funded research collaboration with Vernalis to develop Hsp90 inhibitors and the agents identified have been licensed to Novartis. P.W. is also a consultant for Novartis.

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Workman, P., Powers, M. Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer. Nat Chem Biol 3, 455–457 (2007). https://doi.org/10.1038/nchembio0807-455

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