Skip to main content
SpringerLink
Log in

At the crossroad of thiamine degradation and biosynthesis

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

The physiological significance of thiaminase II has escaped our understanding for many years. The recent discovery of a new thiamine salvage pathway shows that this enzyme is involved in the regeneration of precursors for thiamine biosynthesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Proposed thiamine salvage pathway in Bacillus halodurans.

References

  1. Haas Jenkins, A., Schyns, G., Potot, S., Sun, G. & Begley, T.P. Nat. Chem. Biol. 3, 492–497 (2007).

    Article  Google Scholar 

  2. Ealick, S.E. & Begley, T.P. Nature 446, 387–388 (2007).

    Article  CAS  Google Scholar 

  3. Begley, T.P. Nat. Prod. Rep. 23, 15–25 (2006).

    Article  CAS  Google Scholar 

  4. Rodionov, D.A., Vitreschak, A.G., Mironov, A.A. & Gelfand, M.S. J. Biol. Chem. 277, 48949–48959 (2002).

    Article  CAS  Google Scholar 

  5. Jordan, F. Nat. Prod. Rep. 20, 184–201 (2003).

    Article  CAS  Google Scholar 

  6. Toms, A.V., Haas, A.L., Park, J.H., Begley, T.P. & Ealick, S.E. Biochemistry 44, 2319–2329 (2005).

    Article  CAS  Google Scholar 

  7. Campobasso, N., Costello, C.A., Kinsland, C., Begley, T.P. & Ealick, S.E. Biochemistry 37, 15981–15989 (1998).

    Article  CAS  Google Scholar 

  8. Winkler, W., Nahvi, A. & Breaker, R.R. Nature 419, 952–956 (2002).

    Article  CAS  Google Scholar 

  9. Bettendorff, L. et al. Nat. Chem. Biol. 3, 211–212 (2007).

    Article  CAS  Google Scholar 

  10. Nghiêm, H.O., Bettendorff, L. & Changeux, J.P. FASEB J. 14, 543–554 (2000).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lucien Bettendorff is at the Center for Cellular and Molecular Neurobiology, University of Liège, Building B36, 1, avenue de l'Hôpital, B-4000 Liège, Belgium. l.bettendorff@ulg.ac.be,

    Lucien Bettendorff

Authors
  1. Lucien Bettendorff
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bettendorff, L. At the crossroad of thiamine degradation and biosynthesis. Nat Chem Biol 3, 454–455 (2007). https://doi.org/10.1038/nchembio0807-454

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0807-454

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation