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Encoding chemistry

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A new methodology combining small molecules and phage-displayed peptides enables the isolation of chemically modified bicyclic peptides capable of high-affinity recognition of target proteins.

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Figure 1: Schematic representation of display methodologies for the construction of large repertoires of macromolecules or smaller organic molecules.

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Authors and Affiliations

  1. Dario Neri and André W. Brändli are in the Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland.,

    Dario Neri & André W Brändli

Authors
  1. Dario Neri
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  2. André W Brändli
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Corresponding author

Correspondence to Dario Neri.

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Competing interests

D.N. is a cofounder and shareholder of Philogen (www.philogen.com), a company that develops biotech products originating from phage display libraries and DNA-encoded chemical libraries.

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Neri, D., Brändli, A. Encoding chemistry. Nat Chem Biol 5, 452–453 (2009). https://doi.org/10.1038/nchembio0709-452

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