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Unraveling a molecular target of macrolides

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Leucascandrolide A and neopeltolide are structurally related natural products with potent growth inhibitory activity. The synthesis of a designed analog of leucascandrolide A and its evaluation in a yeast haploinsufficiency screen has revealed the cytochrome bc1 complex as a molecular target of these compounds.

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Figure 1: The simplified leucascandrolide analog 3 and the natural product neopeltolide were obtained through chemical synthesis and shown to be inhibitors of cytochrome bc1.

References

  1. Cragg, G.M. et al. Pure Appl. Chem. 77, 7–24 (2005).

    Article  CAS  Google Scholar 

  2. D'Ambrosio, M. et al. Helv. Chim. Acta 59, 51–60 (1996).

    Article  Google Scholar 

  3. Ulanovskaya, O.A. et al. Nat. Chem. Biol. 4, 418–424 (2008).

    Article  CAS  Google Scholar 

  4. Wright, A.E. et al. J. Nat. Prod. 70, 412–416 (2007).

    Article  CAS  Google Scholar 

  5. Wang, Y. et al. Pure Appl. Chem. 77, 1161–1169 (2005).0

    Article  CAS  Google Scholar 

  6. Feyen, F. et al. Acc. Chem. Res. 41, 21–31 (2008).

    Article  CAS  Google Scholar 

  7. Baetz, K. et al. Proc. Natl. Acad. Sci. USA 101, 4525–4530 (2004).

    Article  CAS  Google Scholar 

  8. Fisher, N. & Meunier, B. FEMS Yeast Res. 8, 183–192 (2008).

    Article  CAS  Google Scholar 

  9. von Kleist-Retzow, J.C. et al. Exp. Cell Res. 313, 3076–3089 (2007).

    Article  CAS  Google Scholar 

  10. Hunte, C., Palsdottir, H. & Trumpower, B.L. FEBS Lett. 545, 39–46 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Karl-Heinz Altmann and Erick M. Carreira are at the Department of Chemistry and Applied Biosciences of the Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli-Str. 10, CH-8093 Zürich, Switzerland. karl-heinz.altmann@pharma.ethz.ch or erickm.carreira@org.chem.ethz.ch,

    Karl-Heinz Altmann & Erick M Carreira

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  1. Karl-Heinz Altmann
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  2. Erick M Carreira
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Altmann, KH., Carreira, E. Unraveling a molecular target of macrolides. Nat Chem Biol 4, 388–389 (2008). https://doi.org/10.1038/nchembio0708-388

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