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Discovery of a new 'dynasore'

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Dynamin is a large GTPase that participates in the severing of membrane-bound vesicles. A small-molecule inhibitor specific for the dynamin family of GTPases has been identified and reveals new aspects of membrane dynamics.

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Figure 1: Previously, methods such as siRNA and expression of dominant-negative dynamin have been used to test dynamin-mediated processes.

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Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology and at the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, 55905, Minnesota, USA

    Heather M Thompson & Mark A McNiven

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  1. Heather M Thompson
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  2. Mark A McNiven
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Thompson, H., McNiven, M. Discovery of a new 'dynasore'. Nat Chem Biol 2, 355–356 (2006). https://doi.org/10.1038/nchembio0706-355

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