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A photochemical snapshot of CD22 binding

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Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.

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Figure 1: CD22 binding partners and photoaffinity cross-linking.

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Authors and Affiliations

  1. Department of Biomedical Engineering, The Johns Hopkins University, Clark Hall 106A, 3400 North Charles Street, Baltimore, 21218, Maryland, USA

    Kevin J Yarema & Zhonghui Sun

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  1. Kevin J Yarema
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  2. Zhonghui Sun
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Yarema, K., Sun, Z. A photochemical snapshot of CD22 binding. Nat Chem Biol 1, 69–70 (2005). https://doi.org/10.1038/nchembio0705-69

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  • DOI: https://doi.org/10.1038/nchembio0705-69

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