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S1P1 signaling just keeps going and going and going...

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An Erratum to this article was published on 01 December 2009

This article has been updated

Synthetic agonists of sphingosine-1-phosphate receptor subtype 1 are able to generate long-term signaling that persists for hours after ligand-induced receptor internalization. These signals are independent of agonist potency, can be reversed after receptor internalization by specific antagonists, and show a distinct acyl-chain-length structure-activity relationship.

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Figure 1: Effect of S1P1 signaling and trafficking in response to different agonists.

Change history

  • 13 November 2009

    In the version of this article initially published, the chemical structures for AFD-R, FTY720-P and OC5 were incorrect. The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Stuart Cahalan and Hugh Rosen are in the Departments of Chemical Physiology and Immunology, The Scripps Research Institute,, La Jolla California, USA. hrosen@scripps.edu,

    Stuart Cahalan & Hugh Rosen

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  1. Stuart Cahalan
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  2. Hugh Rosen
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Cahalan, S., Rosen, H. S1P1 signaling just keeps going and going and going.... Nat Chem Biol 5, 377–378 (2009). https://doi.org/10.1038/nchembio0609-377

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