Efficient transport by single two-headed motor proteins requires coordination of the motor domains. A new single-molecule study sheds light on an important coordination mechanism by demonstrating an asymmetric strain dependence of the weak-to-strong binding transition in myosin-VI heads.
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Lindén, M. Pulling out the coordination mechanism of myosin-VI. Nat Chem Biol 5, 376–377 (2009). https://doi.org/10.1038/nchembio0609-376
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DOI: https://doi.org/10.1038/nchembio0609-376
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