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Chemical answers to epigenetic crosstalk

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Crosstalk between histone modifications plays an important role in transcriptional regulation. In a recent study, an elegant chemical synthesis approach has been used to study the intricate relationship between two modifications associated with active transcription.

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Figure 1: Making of synthetic uH2B for hDot1L-mediated methyltransferase assay.

References

  1. Briggs, S.D. et al. Nature 418, 498 (2002).

    Article  CAS  Google Scholar 

  2. Dover, J. et al. J. Biol. Chem. 277, 28368–28371 (2002).

    Article  CAS  Google Scholar 

  3. Ng, H.H., Xu, R.M., Zhang, Y. & Struhl, K. J. Biol. Chem. 277, 34655–34657 (2002).

    Article  CAS  Google Scholar 

  4. Sun, Z.W. & Allis, C.D. Nature 418, 104–108 (2002).

    Article  CAS  Google Scholar 

  5. McGinty, R.K., Kim, J., Chatterjee, C., Roeder, R.G. & Muir, T.W. Nature published online, doi: 10.1038/nature06906 (30 April 2008).

    Google Scholar 

  6. Martin, C. & Zhang, Y. Nat. Rev. Mol. Cell Biol. 6, 838–849 (2005).

    Article  CAS  Google Scholar 

  7. Minsky, N. et al. Nat. Cell Biol. 10, 483–488 (2008).

    Article  CAS  Google Scholar 

  8. Shogren-Knaak, M. et al. Science 311, 844–847 (2006).

    Article  CAS  Google Scholar 

  9. Simon, M.D. et al. Cell 128, 1003–1012 (2007).

    Article  CAS  Google Scholar 

  10. Robzyk, K., Recht, J. & Osley, M.A. Science 287, 501–504 (2000).

    Article  CAS  Google Scholar 

  11. van Leeuwen, F., Gafken, P.R. & Gottschling, D.E. Cell 109, 745–756 (2002).

    Article  CAS  Google Scholar 

  12. Henry, K.W. et al. Genes Dev. 17, 2648–2663 (2003).

    Article  CAS  Google Scholar 

  13. Klose, R.J. & Zhang, Y. Nat. Rev. Mol. Cell Biol. 8, 307–318 (2007).

    Article  CAS  Google Scholar 

  14. Wang, H. et al. Nature 431, 873–878 (2004).

    Article  CAS  Google Scholar 

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Lee, N., Zhang, Y. Chemical answers to epigenetic crosstalk. Nat Chem Biol 4, 335–337 (2008). https://doi.org/10.1038/nchembio0608-335

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