Crosstalk between histone modifications plays an important role in transcriptional regulation. In a recent study, an elegant chemical synthesis approach has been used to study the intricate relationship between two modifications associated with active transcription.
References
Briggs, S.D. et al. Nature 418, 498 (2002).
Dover, J. et al. J. Biol. Chem. 277, 28368–28371 (2002).
Ng, H.H., Xu, R.M., Zhang, Y. & Struhl, K. J. Biol. Chem. 277, 34655–34657 (2002).
Sun, Z.W. & Allis, C.D. Nature 418, 104–108 (2002).
McGinty, R.K., Kim, J., Chatterjee, C., Roeder, R.G. & Muir, T.W. Nature published online, doi: 10.1038/nature06906 (30 April 2008).
Martin, C. & Zhang, Y. Nat. Rev. Mol. Cell Biol. 6, 838–849 (2005).
Minsky, N. et al. Nat. Cell Biol. 10, 483–488 (2008).
Shogren-Knaak, M. et al. Science 311, 844–847 (2006).
Simon, M.D. et al. Cell 128, 1003–1012 (2007).
Robzyk, K., Recht, J. & Osley, M.A. Science 287, 501–504 (2000).
van Leeuwen, F., Gafken, P.R. & Gottschling, D.E. Cell 109, 745–756 (2002).
Henry, K.W. et al. Genes Dev. 17, 2648–2663 (2003).
Klose, R.J. & Zhang, Y. Nat. Rev. Mol. Cell Biol. 8, 307–318 (2007).
Wang, H. et al. Nature 431, 873–878 (2004).
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Lee, N., Zhang, Y. Chemical answers to epigenetic crosstalk. Nat Chem Biol 4, 335–337 (2008). https://doi.org/10.1038/nchembio0608-335
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DOI: https://doi.org/10.1038/nchembio0608-335
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